全文获取类型
收费全文 | 96456篇 |
免费 | 46711篇 |
国内免费 | 1642篇 |
专业分类
耳鼻咽喉 | 1637篇 |
儿科学 | 4468篇 |
妇产科学 | 695篇 |
基础医学 | 17633篇 |
口腔科学 | 5481篇 |
临床医学 | 15066篇 |
内科学 | 25528篇 |
皮肤病学 | 7775篇 |
神经病学 | 14118篇 |
特种医学 | 3056篇 |
外国民族医学 | 5篇 |
外科学 | 15681篇 |
综合类 | 5694篇 |
现状与发展 | 5篇 |
一般理论 | 22篇 |
预防医学 | 6144篇 |
眼科学 | 1899篇 |
药学 | 8230篇 |
24篇 | |
中国医学 | 2772篇 |
肿瘤学 | 8876篇 |
出版年
2024年 | 67篇 |
2023年 | 420篇 |
2022年 | 688篇 |
2021年 | 2438篇 |
2020年 | 5957篇 |
2019年 | 11464篇 |
2018年 | 10813篇 |
2017年 | 12131篇 |
2016年 | 12674篇 |
2015年 | 12877篇 |
2014年 | 12960篇 |
2013年 | 13486篇 |
2012年 | 5785篇 |
2011年 | 5696篇 |
2010年 | 10050篇 |
2009年 | 6267篇 |
2008年 | 3182篇 |
2007年 | 2202篇 |
2006年 | 2008篇 |
2005年 | 1708篇 |
2004年 | 1926篇 |
2003年 | 2266篇 |
2002年 | 2131篇 |
2001年 | 1984篇 |
2000年 | 1366篇 |
1999年 | 674篇 |
1998年 | 237篇 |
1997年 | 251篇 |
1996年 | 172篇 |
1995年 | 146篇 |
1994年 | 167篇 |
1993年 | 86篇 |
1992年 | 103篇 |
1991年 | 74篇 |
1990年 | 61篇 |
1989年 | 58篇 |
1988年 | 50篇 |
1987年 | 37篇 |
1986年 | 32篇 |
1985年 | 25篇 |
1984年 | 11篇 |
1983年 | 11篇 |
1982年 | 13篇 |
1981年 | 7篇 |
1980年 | 3篇 |
1979年 | 5篇 |
1978年 | 3篇 |
1933年 | 3篇 |
1929年 | 2篇 |
1928年 | 3篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
2.
Jiang Guoxiang Zhang Ruihua Yang Xuan Zhang Wen Hou Yubin 《Clinical and experimental medicine》2022,22(2):193-200
Clinical and Experimental Medicine - Colon cancer is one of most common cancers. The progression of various cancers is driven by miRNA-570. The role of miRNA-570 in the progression of colon cancer... 相似文献
3.
Mette Nissen Tiina‐Mari Ikheimo Jukka Huttunen Ville Leinonen Henna‐Kaisa Jyrkknen Mikael von und zu Fraunberg 《Neuromodulation》2021,24(1):102-111
ObjectiveSpinal cord stimulation (SCS) is an effective treatment in failed back surgery syndrome (FBSS). We studied the effect of preimplantation opioid use on SCS outcome and the effect of SCS on opioid use during a two-year follow-up period.Materials and methodsThe study cohort included 211 consecutive FBSS patients who underwent an SCS trial from January 1997 to March 2014. Participants were divided into groups, which were as follows: 1) SCS trial only (n = 47), 2) successful SCS (implanted and in use throughout the two-year follow-up period, n = 131), and 3) unsuccessful SCS (implanted but later explanted or revised due to inadequate pain relief, n = 29). Patients who underwent explantation for other reasons (n = 4) were excluded. Opioid purchase data from January 1995 to March 2016 were retrieved from national registries.ResultsHigher preimplantation opioid doses associated with unsuccessful SCS (ROC: AUC = 0.66, p = 0.009), with 35 morphine milligram equivalents (MME)/day as the optimal cutoff value. All opioids were discontinued in 23% of patients with successful SCS, but in none of the patients with unsuccessful SCS (p = 0.004). Strong opioids were discontinued in 39% of patients with successful SCS, but in none of the patients with unsuccessful SCS (p = 0.04). Mean opioid dose escalated from 18 ± 4 MME/day to 36 ± 6 MME/day with successful SCS and from 22 ± 8 MME/day to 82 ± 21 MME/day with unsuccessful SCS (p < 0.001).ConclusionsHigher preimplantation opioid doses were associated with SCS failure, suggesting the need for opioid tapering before implantation. With continuous SCS therapy and no explantation or revision due to inadequate pain relief, 39% of FBSS patients discontinued strong opioids, and 23% discontinued all opioids. This indicates that SCS should be considered before detrimental dose escalation. 相似文献
4.
5.
人工智能(Artificial Intelligence,AI)的蓬勃兴起为现代社会带来了前所未有的机遇,中医药是中华民族传承千年的文化瑰宝。随着人工智能技术不断在中医药领域的科技创新中崭露头角,二者的融合不断加深,人工智能在中医药领域的发展前景、争议挑战也引发了诸多思考。本文将从人工智能在中医药领域的应用入手,对人工智能辅助中医诊断、智能决策与数据挖掘、健康管理及中草药现代化研究等方面,就近年来国内外研究进展进行总结与分析,以期为AI视域下实现中医药现代化、智能化赋能。 相似文献
6.
Sung‐Hyun Hwang Myung‐Chul Kim Sumin Ji Yeseul Yang Yeji Jeong Yongbaek Kim 《Cancer science》2019,110(4):1256-1267
Metformin, a drug for type 2 diabetes mellitus, has shown therapeutic effects for various cancers. However, it had no beneficial effects on the survival rate of human malignant mesothelioma (HMM) patients. The present study was performed to elucidate the underlying mechanism of metformin resistance in HMM cells. Glucose‐starved HMM cells had enhanced resistance to metformin, demonstrated by decreased apoptosis and autophagy and increased cell survival. These cells showed abnormalities in mitochondria, such as decreased ATP synthesis, morphological elongation, altered mitochondrial permeability transition pore and hyperpolarization of mitochondrial membrane potential (MMP). Intriguingly, Mdr1 was significantly upregulated in mitochondria but not in cell membrane. The upregulated mitochondrial Mdr1 was reversed by treatment with carbonyl cyanide m‐chlorophenyl hydrazone, an MMP depolarization inducer. Furthermore, apoptosis and autophagy were increased in multidrug resistance protein 1 knockout HMM cells cultured under glucose starvation with metformin treatment. The data suggest that mitochondrial Mdr1 plays a critical role in the chemoresistance to metformin in HMM cells, which could be a potential target for improving its therapeutic efficacy. 相似文献
7.
8.
Evelyne Harkemanne Jean‐Louis Dargent Pierre‐Paul Roquet‐Gravy Audrey Bulinckx 《Pediatric dermatology》2019,36(3):365-367
We report a case of benign lymphoplasmacytic plaque (LPP) in a child. These asymptomatic erythematous papulonodular lesions are an emerging clinicopathological entity. Herein, we describe a previously unreported site for LPP lesions, namely, the volar wrist and the distal ipsilateral palm. 相似文献
9.
10.